<p>Spinal N-Cadherin/CREB Signaling Contributes to Chronic Alcohol Consumption-Enhanced Postsurgical Pain</p>

Chronic Alcohol Consumption Impairs

Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-kappaB and STAT3 signaling pathways.

Alcohol consumption is a major risk factor accelerating the progression of liver disease in patients with chronic hepatitis virus infection. However, the mechanism underlying the enhanced susceptibility of alcoholics to liver injury is not fully understood. Here, we demonstrate that chronic ethanol consumption increases the susceptibility of C57BL/6 mice to concanavalin A (Con A)-induced T cell...

Epidemiology of Chronic Postsurgical Pain

Chronic postsurgical pain has a global incidence of 30 %, while surgery is the second commonest cause of neuropathic pain. The operations most commonly implicated in chronic postsurgical pain are inguinal hernia repair, breast surgery, amputation, cholecystectomy and thoracotomy. Possible risk factors are the existence of preoperative pain, psychological characteristics of the patient, certain ...

CXCL12/CXCR4 signaling-mediated ERK1/2 activation in spinal cord contributes to the pathogenesis of postsurgical pain in rats

Background It has been demonstrated that upregulation of CXCL12 and CXCR4 in spinal cord involves in the pathogenesis of neuropathic, inflammatory, and cancer pain. However, whether CXCL12/CXCR4 signaling contributes to postsurgical pain remains unknown. The aim of the present study is to investigate the role of CXCL12/CXCR4 signaling in the genesis of postsurgical pain and the underlying mecha...

Ascorbic Acid and Chronic Alcohol Consumption in the Guinea Pig’

Ascorbic Acid and Chronic Alcohol Consumption in the Guinea Pig. SUSICK, R. L., JR., ABRAM& G. D., ZURAWSKI, C. A., AND ZANNONI, V. G. (1986). Toxicol. Appl. Pharmacol. 84,329-335. Protection against the toxic effects of chronic alcohol consumption was observed in male guinea pigs maintained on a high-ascorbic-acid diet (vitamin C-deficient chow plus 2.0 mg ascorbic acid/ml drinking water) as c...